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Untreated, some depressive symptoms associated with anabolic steroid withdrawal have been known to persist for a year or more after the abuser stops taking the drugs. (This is why a lot of athletes try to get the drug kicked off their system before they retire.)One of the studies analyzed a group of women whose weight loss was slowed or stopped by prescription anti-depressants including Prozac and Zoloft. In those who stopped taking both drugs, symptoms of depression, including irritability, depression and sleep problems, returned to normal in eight months.The researchers who published the study conclude that "the long-term use of anabolic steroids [including anabolic steroids] for a number of years has a significant adverse effect on the psychological health of abusers."However, there are signs that the drugs could also serve as powerful antidepressants. In one study, researchers found that, when patients with bipolar depression who were taking medication for at least one other psychiatric disorder had an "early adverse event" or "event" before being diagnosed with depression, the patients were much more likely to be prescribed an anabolic steroid.Another study of 1,300 patients who received a placebo or an anabolic steroid injection found that patients who received the anabolic steroid had an improvement in symptoms of depression. "Our findings suggest that antidepressants may have a role in the treatment of anabolic steroid withdrawal," the researchers wrote in the study, which has recently been published in the journal Archives of General Psychiatry.Related Article: